French researchers find treating with anti-Aids drugs soon after infection could control virus in some patients
Treating people with HIV rapidly after they have become infected with the virus that causes Aids may be enough to achieve a “functional cure” in a small proportion of patients diagnosed early, according to research.
Scientists in France who followed 14 patients who were treated swiftly with HIV drugs but then stopped treatment found that even when they had been off therapy for more than seven years they still showed no signs of the virus rebounding.
The research, published in the journal PLOS Pathogens, follows news this month about a baby girl in Mississippi being effectively cured of HIV after receiving early treatment.
Christine Rouzioux, a professor at Paris Descartes University and a member of the team that identified HIV 30 years ago, said the results showed that the number of infected cells circulating in the blood of these patients, who are known as “post-treatment controllers”, kept falling even without treatment for many years.
“Early treatment in these patients may have limited the establishment of viral reservoirs, the extent of viral mutations, and preserved immune responses. A combination of those may contribute to control infection in post-treatment controllers,” she said.
“The shrinking of viral reservoirs … closely matches the definition of ‘functional’ cure,” she said.
A functional cure is when the virus is reduced to such low levels that it is kept at bay even without continuing treatment. The virus is still detectable in the body.
Most of the 34 million people with HIV around the world will have to take anti-Aids drugs known as antiretroviral therapy for the whole of their lives. These drugs generally keep the disease in check but also have side-effects and are expensive.
Worldwide, the number of people newly infected with HIV, which can be transmitted via blood and breast milk and during sex, is falling. At 2.5 million, the number of new infections in 2011 was 20% lower than in 2001, according to the UN Aids programme. And deaths from Aids fell to 1.7 million in 2011, down from a peak of 2.3 million in 2005.
Asier Sáez-Cirión, a senior HIV researcher at the Pasteur Institute in Paris, said that although most patients will not be able to control HIV, these results suggest that some may be able to if they get treatment early enough.
This data “and the Mississippi study strongly support early treatment initiation and may hold important clues for the development of a strategy to cure HIV or at least induce a long-term control without the need of antiretroviral treatment”, he said.